Coenzyme Q10is used as a natural headache preventive. For migraine prevention, the recommended amount is 300mg a day, ideally as 150mg twice a day or 100mg three times a day. It takes about 3 months to work. There aren’t a lot of studies because doing a study can be costly and pharmaceutical companies, which fund a lot of studies, are not interested in funding studies for natural substances. For this reason also, the number of subjects in the study are small too.
A coenzyme is a a substance that helps the enzyme do its job better and faster. You need plenty of coenzymes in order to have all the helpers that the enzyme needs to do its job well. I included an article by Dr. Al Sears who explains this in more detail. Coenzyme Q10 is used for other health reasons too.
There are no recorded side-effects of coenzyme Q10. But, I did have one patient who had some skin sensitivity to it.
In one study, 42 patients were given a liquid formulation of coenzyme Q10 or a placebo. The dose given was 300mg/day divided as 100mg/d three times a day.
By month four, almost 50% of the patients taking coenzyme Q10 had their headache frequency cut in half.